TDP1 Rabbit Polyclonal Antibody (CAB4849)
- SKU:
- CAB4849
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- TDP1
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | TDP1 Rabbit Polyclonal Antibody |
SKU: | CAB4849 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human TDP1 (NP_060789.2). |
Sequence: | MSQE GDYG RWTI SSSD ESEE EKPK PDKP STSS LLCA RQGA ANEP RYTC SEAQ KAAH KRKI SPVK FSNT DSVL PPKR QKSG SQED LGWC LSSS DDEL QPEM PQKQ AEKV VIKK EKDI SAPN DGTA QRTE NHGA PACH RLKE |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | TDP1 |
Positive Sample: | HL-60,DU145,Rat thymus |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 68kDa |
Observed MW: | 70kDa |
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1).
Purification Method: | Affinity purification |
Gene ID: | 55775 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |