null

TDP1 Monoclonal Antibody [PAT1F2AT] (CPAB0166)

SKU:
CPAB0166
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2b
Clone:
PAT1F2AT
Applications:
WB
ELISA
€149
Frequently bought together:

Description

system_update_alt Datasheet

TDP1 Monoclonal Antibody [PAT1F2AT] (CPAB0166)

The TDP1 Polyclonal Antibody (CPAB0166) is a key tool for researchers studying TDP1, a DNA repair enzyme critical for maintaining genomic stability. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot applications. By binding to the TDP1 protein, this antibody enables precise detection and analysis in a variety of cell types, facilitating investigations in DNA repair mechanisms and their implications in diseases such as cancer and neurodegenerative disorders.

TDP1, also known as tyrosyl-DNA phosphodiesterase 1, plays a crucial role in repairing DNA damage caused by topoisomerase inhibitors and oxidative stress. Dysregulation of TDP1 function has been linked to genomic instability and increased susceptibility to cancer and neurodegenerative diseases. By studying the role of TDP1, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention.

Product Name:TDP1 Antibody
Product Sku:CPAB0166
Size:5μg
Host Species:Mouse
Immunogen:Anti-human TDP1 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human TDP1 amino acids 1-298 purified from Ecoli.
Clone:PAT1F2AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:TDP1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG2b
Background:TDP1 belongs to the phospholipase D family and contains two PLD phosphodiesterase domains. TDP1 is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. TDP1 may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. Mutations in the TDP1 gene are linked to the disease spinocerebellar ataxia with axonal neuropathy (SCAN1).
Synonyms:Tyrosyl-DNA phosphodiesterase 1, Tyr-DNA phosphodiesterase 1, TDP1, FLJ11090, MGC104252.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

Related Products