The TDO2 Polyclonal Antibody (CAB6766) is a powerful tool for researchers studying TDO2, an enzyme involved in the regulation of tryptophan metabolism in immune response and inflammation. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the TDO2 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an excellent choice for studies in immunology, cancer research, and metabolic disorders.TDO2, also known as tryptophan 2,3-dioxygenase, is a key player in the kynurenine pathway, which influences immune tolerance and response to inflammation.
Dysregulation of TDO2 activity has been implicated in various diseases, including cancer, autoimmune disorders, and psychiatric conditions. By uncovering the role of TDO2 in these pathological processes, researchers can develop targeted therapies that modulate tryptophan metabolism for therapeutic benefit.Overall, the TDO2 Polyclonal Antibody is a valuable tool for investigating the role of TDO2 in health and disease, providing crucial insights into immune regulation and metabolic pathways that may pave the way for novel therapeutic interventions.
Product Name:
TDO2 Rabbit Polyclonal Antibody
SKU:
CAB6766
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human TDO2 (NP_005642.1).
This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.
Purification Method:
Affinity purification
Gene ID:
6999
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of HUH-7, using TDO2 antibody (CAB6766) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
