TDG Rabbit Polyclonal Antibody (CAB5756)
- SKU:
- CAB5756
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | TDG Rabbit Polyclonal Antibody |
SKU: | CAB5756 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human TDG (NP_003202.3). |
Sequence: | MEAE NAGS YSLQ QAQA FYTF PFQQ LMAE APNM AVVN EQQM PEEV PAPA PAQE PVQE APKG RKRK PRTT EPKQ PVEP KKPV ESKK SGKS AKSK EKQE KITD TFKV KRKV DRFN GVSE AELL TKTL PDIL TFNL DIVI IGIN PGLM AAYK GHHY PGPG NHFW |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | hTDG; TDG |
Positive Sample: | Rat thymus |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 46kDa |
Observed MW: | 50kDa |
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
Purification Method: | Affinity purification |
Gene ID: | 6996 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |