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TDG Monoclonal Antibody [PAT2F7A] (CPAB0173)

SKU:
CPAB0173
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
PAT2F7A
Applications:
WB
ELISA
€149
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Description

system_update_alt Datasheet

TDG Monoclonal Antibody [PAT2F7A] (CPAB0173)

The TDG Antibody (CPAB0173) is a highly specific and sensitive tool for studying TDG, an important enzyme involved in DNA demethylation processes. This polyclonal antibody, produced in rabbits, is optimized for detecting TDG protein in human samples and is validated for use in Western blot experiments, providing reliable and reproducible results.TDG plays a crucial role in maintaining genome stability and regulating gene expression by actively removing 5-methylcytosine from DNA. Dysregulation of TDG activity has been implicated in various diseases, including cancer and neurological disorders.

Therefore, investigating the expression and function of TDG using the CPAB0173 antibody can offer valuable insights into the molecular mechanisms underlying these pathologies.Researchers in the fields of genetics, epigenetics, and oncology can benefit from the high specificity and sensitivity of the TDG Antibody (CPAB0173) in their studies. By targeting TDG, this antibody enables precise detection and characterization of the protein, facilitating a deeper understanding of its biological functions and potential therapeutic implications in disease treatment.

Product Name:TDG Antibody
Product Sku:CPAB0173
Size:5μg
Host Species:Mouse
Immunogen:Anti-human TDG mAb, clone PAT2F7A, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human TDG protein 1-41 amino acids purified from Ecoli.
Clone:PAT2F7A.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:
Isotype:IgG1
Background:Thymine-DNA glycosylase (TDG) is a member of the TDG/mug DNA glycosylase family. TDG is a nuclear protein that fixes G/T mismatches to G/C pairs by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired thymin. In addition, TDG removes uracil and 5-bromouracil from mispairings with guanine. The TDG enzyme has an essential role in cellular defense against genetic mutation triggered by the spontaneous deamination of 5-methylcytosine and cytosine.
Synonyms:Thymine-DNA Glycosylase, G/T Mismatch-Specific Thymine DNA Glycosylase, EC 3.2.2.29.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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