The TCTN1 Polyclonal Antibody (CAB14929) is a valuable tool for researchers studying TCTN1, a protein involved in ciliogenesis and signaling pathways within cells. This antibody, generated in rabbits, exhibits high specificity and sensitivity in detecting TCTN1 in human samples, making it ideal for Western blot analysis.TCTN1 is a key player in cilium formation and function, crucial for cellular signaling and sensory processes. Dysregulation of TCTN1 has been implicated in various diseases, including ciliopathies and certain cancers.
By targeting TCTN1 with this antibody, researchers can better understand its role in cell biology and disease progression.Whether investigating ciliary structure and function or exploring TCTN1's impact on disease mechanisms, this polyclonal antibody provides a reliable tool for researchers in cell biology, genetics, and developmental biology. Its versatility and specificity make it a valuable asset in advancing our knowledge of TCTN1 biology and its implications in human health.
Product Name:
TCTN1 Rabbit Polyclonal Antibody
SKU:
CAB14929
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 130-310 of human TCTN1 (NP_001076006.1).
This gene encodes a member of a family of secreted and transmembrane proteins. The orthologous gene in mouse functions downstream of smoothened and rab23 to modulate hedgehog signal transduction. This protein is a component of the tectonic-like complex, which forms a barrier between the ciliary axoneme and the basal body. A mutation in this gene was found in a family with Joubert syndrome-13. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
79600
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TCTN1 Rabbit pAb (CAB14929) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
