The TCP1-beta Rabbit Monoclonal Antibody (CAB4700) is a valuable tool for researchers studying TCP1-beta, a key subunit of the TCP1 complex involved in protein folding and assembly. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in various applications including Western blotting.TCP1-beta, also known as Cct2, plays a crucial role in the chaperonin-containing TCP1 (CCT) complex, which assists in the folding of cytosolic proteins. Dysregulation of TCP1-beta has been linked to various diseases, including neurodegenerative disorders and cancer, making it a promising target for therapeutic interventions.
By specifically binding to TCP1-beta, this monoclonal antibody enables researchers to detect and analyze the protein in different cell types, offering insights into its function and potential mechanisms of action. Its reliability and specificity make it an essential tool for investigations in the fields of protein folding, cellular biology, and disease research.
Product Name:
TCP1 beta/CCT2 Rabbit Monoclonal Antibody
SKU:
CAB4700
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 436-535 of human TCP1 beta/CCT2 (P78371).
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10576
Clone Number:
ARC1097
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using TCP1 beta/CCT2 Rabbit mAb (CAB4700) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
