TCL1A Rabbit Polyclonal Antibody (CAB0629)
- SKU:
- CAB0629
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | TCL1A Rabbit Polyclonal Antibody |
SKU: | CAB0629 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human TCL1A (NP_001092195.1). |
Sequence: | MAEC PTLG EAVT DHPD RLWA WEKF VYLD EKQH AWLP LTIE IKDR LQLR VLLR REDV VLGR PMTP TQIG PSLL PIMW QLYP DGRY RSSD SSFW RLVY HIKI DGVE DMLL ELLP DD |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | TCL1; TCL1A |
Positive Sample: | Ramos |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus. |
Calculated MW: | 13kDa |
Observed MW: | 16kDa |
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).
Purification Method: | Affinity purification |
Gene ID: | 8115 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |