The TCL1A Antibody (CAB0629) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody is generated in rabbits and has a high specificity for human samples, making it ideal for use in Western blot applications to detect and analyze TCL1A expression in various types of cells.TCL1A is a key player in promoting cell growth and survival, particularly in lymphoid cells, and its overexpression has been linked to the pathogenesis of certain types of lymphomas and leukemias.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
TCL1A Antibody
SKU:
CAB0629
Size:
20μL, 100μL
Reactivity:
Human
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).
Purification Method
Affinity purification
Gene ID
8115
RRID
AB_2757302
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of lysates from Ramos cells, using TCL1A Rabbit pAb (CAB0629) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
