The TCIRG1 Polyclonal Antibody (CAB15382) is a valuable tool for researchers studying the TCIRG1 protein, which is essential for osteoclast function and bone resorption. This antibody, generated in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the TCIRG1 protein, this antibody allows for precise detection and analysis in various cell types, making it ideal for research in bone biology and related diseases.TCIRG1, also known as Osteoclast-specific proton pump subunit, is a key player in bone remodeling and maintaining bone density.
Imbalances in TCIRG1 function have been associated with osteoporosis, osteopetrosis, and other bone-related disorders. Understanding the role of TCIRG1 in bone metabolism is crucial for developing targeted therapies for these conditions.Researchers studying bone physiology, osteoporosis, and related disorders will find the TCIRG1 Polyclonal Antibody to be a valuable resource for their experiments. Its specificity and reliability make it an essential tool for investigating the intricate mechanisms of bone resorption and remodeling.
Product Name:
TCIRG1 Rabbit Polyclonal Antibody
SKU:
CAB15382
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human TCIRG1 (NP_006010.2).
This gene encodes a subunit of a large protein complex known as a vacuolar H+-ATPase (V-ATPase). The protein complex acts as a pump to move protons across the membrane. This movement of protons helps regulate the pH of cells and their surrounding environment. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Alternative splicing results in multiple transcript variants. Mutations in this gene are associated with infantile malignant osteopetrosis.
Purification Method:
Affinity purification
Gene ID:
10312
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse spleen, using TCIRG1 Rabbit pAb (CAB15382) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
