TCF7 Rabbit Polyclonal Antibody (CAB3091)
- SKU:
- CAB3091
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | TCF7 Rabbit Polyclonal Antibody |
SKU: | CAB3091 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human TCF1/TCF7 (NP_003193.2). |
Sequence: | ELKS SLVN ESEG AAGG AGIP GVPG AGAG ARGE AEAL GREH AAQR LFPD KLPE PLED GLKA PECT SGMY KETV YSAF NLLM HYPP PSGA GQHP QPQP PLHK A |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | TCF-1; TCF1/TCF7 |
Positive Sample: | HT-29,Jurkat,Mouse spleen,Mouse thymus,Rat lung,Rat spleen |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 42kDa |
Observed MW: | 28-50kDa |
This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling.
Purification Method: | Affinity purification |
Gene ID: | 6932 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |