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TCF4/TCF12 Antibody (PACO01598)

SKU:
PACO01598
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

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TCF4/TCF12 Antibody (PACO01598)

The TCF4/TCF12 Antibody (PACO01598) is a highly specific and reliable tool for research involving the transcription factors TCF4 and TCF12. These proteins are key players in the Wnt signaling pathway, which plays a crucial role in cell proliferation, differentiation, and stem cell maintenance. This antibody, produced using cutting-edge technology, is validated for use in various experimental applications, including immunofluorescence, immunohistochemistry, and chromatin immunoprecipitation. It specifically binds to TCF4 and TCF12 proteins, allowing for accurate detection and analysis in a variety of cell types and tissues.

Understanding the function of TCF4 and TCF12 is essential for unraveling their roles in development, cancer, and other diseases. By studying these transcription factors, researchers can gain valuable insights into the mechanisms underlying cellular processes and potentially identify new therapeutic targets for various medical conditions. Overall, the TCF4/TCF12 Antibody (PACO01598) is a valuable tool for any scientist seeking to delve deeper into the intricate world of Wnt signaling and its implications in health and disease.

Antibody Name:TCF4/TCF12 Antibody
Antibody SKU:PACO01598
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from the C-terminal region of human TCF-4/12.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:TCF4; BHLHB19; ITF2; SEF2; Transcription factor 4; TCF-4; Class B basic helix-loop-helix protein 19; bHLHb19; Immunoglobulin transcription factor 2; ITF-2; SL3-3 enhancer factor 2; SEF-2; TCF12; BHLHB20; HEB; HTF4; Transcription factor 12;
UniProt Protein Function:TCF4: Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription. Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. Efficient DNA binding requires dimerization with another bHLH protein. Forms homo- or heterooligomers with myogenin. Interacts with HIVEP2. Interacts with NEUROD2. Expressed in adult heart, brain, placenta, skeletal muscle and to a lesser extent in the lung. In developing embryonic tissues, expression mostly occurs in the brain. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 18q21.1

Cellular Component: transcription factor complex; nucleus

Molecular Function:protein C-terminus binding; protein binding; DNA binding; protein heterodimerization activity; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription initiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation; protein-DNA complex assembly

Disease: Corneal Dystrophy, Fuchs Endothelial, 3; Pitt-hopkins Syndrome

NCBI Summary:This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Aug 2011]
UniProt Code:P15884
NCBI GenInfo Identifier:3915747
NCBI Gene ID:6925
NCBI Accession:P15884.3
UniProt Secondary Accession:P15884,B3KT62, B3KUC0, B4DT37, B4DUG3, B7Z5M6, B7Z6Y1 G0LNT9, G0LNU0, G0LNU1, G0LNU2, G0LNU4,
UniProt Related Accession:P15884
Molecular Weight:48,098 Da
NCBI Full Name:Transcription factor 4
NCBI Synonym Full Names:transcription factor 4
NCBI Official Symbol:TCF4  
NCBI Official Synonym Symbols:E2-2; ITF2; PTHS; SEF2; ITF-2; SEF-2; TCF-4; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; bHLHb19  
NCBI Protein Information:transcription factor 4; SL3-3 enhancer factor 2; transcription factor 4, isoform C; transcription factor 4, isoform D; transcription factor 4, isoform E; transcription factor 4, isoform R; immunoglobulin transcription factor 2; class B basic helix-loop-helix protein 19
UniProt Protein Name:Transcription factor 4
UniProt Synonym Protein Names:Class B basic helix-loop-helix protein 19; bHLHb19; Immunoglobulin transcription factor 2; ITF-2; SL3-3 enhancer factor 2; SEF-2
Protein Family:Transcription factor
UniProt Gene Name:TCF4  
UniProt Entry Name:ITF2_HUMAN

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