The TCF4 Polyclonal Antibody (CAB1141) is a valuable tool for researchers studying TCF4, a transcription factor involved in various cellular processes, including cell differentiation and proliferation. This antibody, generated in rabbits, exhibits high reactivity towards human samples and is validated for use in Western blot applications. By binding specifically to the TCF4 protein, this antibody allows for the detection and analysis of TCF4 expression in a variety of cell types, making it an ideal choice for studies in developmental biology and cancer research.TCF4, also known as transcription factor 7-like 2, is a key regulator of gene expression and plays a crucial role in controlling cell fate decisions.
Dysregulation of TCF4 has been implicated in various diseases, including cancer, neurodevelopmental disorders, and gastrointestinal diseases. By understanding the function of TCF4, researchers can shed light on disease mechanisms and identify potential therapeutic targets for these conditions.Overall, the TCF4 Polyclonal Antibody (CAB1141) is a valuable tool for investigating the role of TCF4 in cellular processes and disease pathogenesis, providing valuable insights for the development of novel therapeutic interventions.
Product Name:
TCF4 Rabbit Polyclonal Antibody
SKU:
CAB1141
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human TCF4 (NP_003190.1).
This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described.
Purification Method:
Affinity purification
Gene ID:
6925
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from 293T cells, using TCF4 Rabbit pAb (CAB1141) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
