The TCEB3C Polyclonal Antibody (PAC022062) is a valuable tool for researchers studying TCEB3C, a protein involved in the regulation of gene expression and protein stability. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to TCEB3C, this antibody enables the detection and analysis of the protein in various cell types, making it ideal for investigations in molecular biology and cancer research.
TCEB3C, also known as Elongin A3, plays a crucial role in the ubiquitin-proteasome pathway, which controls the degradation of proteins involved in various cellular processes. Dysregulation of TCEB3C has been implicated in cancer progression and other diseases, making it a promising therapeutic target. By studying the function of TCEB3C with this antibody, researchers can gain insights into its role in disease development and potentially identify new treatment strategies.
Antibody Name:
TCEB3C Antibody (PACO22062)
Antibody SKU:
PACO22062
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human ELOA3.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from COLO cells, using ELOA3 antibody.
Background:
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
Synonyms:
RNA polymerase II transcription factor SIII subunit A3; Elongin-A3; EloA3; Transcription elongation factor B polypeptide 3C; TCEB3C
UniProt Protein Function:
TCEB3C: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).Chromosomal Location of Human Ortholog: 18q21.1Cellular Component: integral to membrane; nucleusMolecular Function: DNA bindingBiological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
The SIII (or elongin) transcription elongation factor complex stimulates the rate of transcription elongation by RNA polymerase II by suppressing the transient pausing of the polymerase at many sites along the DNA template. This complex is a heterotrimer, composed of the transcriptionally active subunit A, A2 or A3 (or elongin A, A2 or A3) and two regulatory subunits, B and C (or elongin B and C). This gene encodes subunit A3. A3 and A are ubiquitously expressed, whereas A2 is specifically expressed in the testis. [provided by RefSeq, Mar 2010]
