The TCEB3C Polyclonal Antibody (PACO02565) is a valuable tool for researchers studying TCEB3C, a protein involved in transcription regulation and cell cycle progression. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for a variety of applications, including Western blotting.TCEB3C, also known as Elongin A3, plays a crucial role in the ubiquitin-proteasome pathway by promoting the degradation of specific proteins involved in gene transcription and cell division. Dysregulation of TCEB3C has been associated with various diseases, including cancer and developmental disorders.
Therefore, studying the function of TCEB3C can provide insights into disease mechanisms and potential therapeutic targets.By utilizing the TCEB3C Polyclonal Antibody (PACO02565), researchers can analyze the expression levels and localization of TCEB3C in different cell types and tissues, facilitating further exploration of its biological functions. This antibody is a valuable tool for advancing research in fields such as oncology, developmental biology, and molecular biology.
Antibody Name:
TCEB3C Antibody
Antibody SKU:
PACO02565
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC, IF
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the C-terminal region of human Elongin A3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
TCEB3C; TCEB3L2; RNA polymerase II transcription factor SIII subunit A3; Elongin-A3; EloA3; Transcription elongation factor B polypeptide 3C
UniProt Protein Function:
TCEB3C: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).Chromosomal Location of Human Ortholog: 18q21.1Cellular Component: integral to membrane; nucleusMolecular Function: DNA bindingBiological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
The SIII (or elongin) transcription elongation factor complex stimulates the rate of transcription elongation by RNA polymerase II by suppressing the transient pausing of the polymerase at many sites along the DNA template. This complex is a heterotrimer, composed of the transcriptionally active subunit A, A2 or A3 (or elongin A, A2 or A3) and two regulatory subunits, B and C (or elongin B and C). This gene encodes subunit A3. A3 and A are ubiquitously expressed, whereas A2 is specifically expressed in the testis. [provided by RefSeq, Mar 2010]
