The TCEB3B/TCEB3C Polyclonal Antibody (PACO04524) is a valuable tool for researchers studying the TCEB3B and TCEB3C proteins, which are components of the Elongin BC complex known to be involved in transcription elongation and ubiquitin ligase activity. This antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting TCEB3B and TCEB3C in human samples, making it ideal for use in Western blotting applications.The TCEB3B/TCEB3C antibody enables researchers to investigate the expression levels and localization of these proteins in various cell types, shedding light on their roles in gene expression regulation and protein degradation pathways.
By elucidating the functions of TCEB3B and TCEB3C, researchers can gain insights into their potential implications in diseases such as cancer, neurodegenerative disorders, and metabolic syndromes.Overall, the TCEB3B/TCEB3C Polyclonal Antibody (PACO04524) provides a reliable and efficient tool for studying the functions and regulatory mechanisms of TCEB3B and TCEB3C in cellular processes, offering valuable insights for advancing research in molecular biology and disease pathology.
Antibody Name:
TCEB3B/TCEB3C Antibody
Antibody SKU:
PACO04524
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
IF:1:200-1:1000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human Elongin A2/3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
NCBI Summary:
This gene encodes the transcriptionally active subunit of the SIII (or elongin) transcription elongation factor complex, which also includes two regulatory subunits, elongins B and C. This complex acts to increase the rate of RNA chain elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites along the DNA template. Whereas a related protein with similar function, elongin A, is ubiquitously expressed, the encoded protein is specifically expressed in the testis, suggesting it may have a role in spermatogenesis. [provided by RefSeq, Jul 2008]
