The TCEB2 Monoclonal Antibody is a cutting-edge tool for researchers studying TCEB2, a protein that plays a key role in the regulation of gene transcription and protein degradation. This antibody, produced using hybridoma technology, specifically targets the TCEB2 protein in human samples and has been validated for use in various experimental applications, including immunofluorescence and flow cytometry.TCEB2, also known as Elongin B, is a subunit of the Elongin complex that is involved in the function of the proteasome, an essential cellular machinery responsible for degrading proteins. By targeting TCEB2 with this monoclonal antibody, researchers can gain valuable insights into the mechanisms underlying protein degradation and gene expression regulation.
This antibody is a valuable tool for studies in molecular biology, cell biology, and biochemistry, providing researchers with the ability to detect and analyze TCEB2 in different cell types and experimental conditions. With its high specificity and sensitivity, the TCEB2 Monoclonal Antibody is a critical resource for unraveling the intricate molecular pathways controlled by TCEB2 and its implications in various physiological and pathological processes.
Product Name:
TCEB2 Monoclonal Antibody
SKU:
CAB21126
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human TCEB2 (NP_009039.1).
This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13.
Purification Method:
Affinity purification
Gene ID:
6923
Clone Number:
ARC3061
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using TCEB2 Rabbit mAb (CAB21126) at1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 45s.
