The TCEB1 Polyclonal Antibody (CAB12515) is a valuable tool for researchers studying TCEB1, a protein involved in the regulation of gene expression and protein degradation. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the TCEB1 protein, this antibody enables detection and analysis in a variety of cell types, making it ideal for studies in molecular biology, cancer research, and drug development.
TCEB1, also known as Elongin C, is a key component of the Elongin complex, which plays a crucial role in targeting proteins for degradation by the proteasome. Dysregulation of TCEB1 expression has been linked to various diseases, including cancer and neurodegenerative disorders. By studying the function of TCEB1, researchers can gain insight into the mechanisms underlying these conditions and potentially identify new therapeutic targets for treatment.
Product Name:
TCEB1 Rabbit Polyclonal Antibody
SKU:
CAB12515
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-112 of human TCEB1 (NP_001191791.1).
This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
6921
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TCEB1 antibody (CAB12515) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
