TCEB1 Rabbit Polyclonal Antibody (CAB12515)
- SKU:
- CAB12515
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | TCEB1 Rabbit Polyclonal Antibody |
SKU: | CAB12515 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-112 of human TCEB1 (NP_001191791.1). |
Sequence: | MDGE EKTY GGCE GPDA MYVK LISS DGHE FIVK REHA LTSG TIKA MLSG PGQF AENE TNEV NFRE IPSH VLSK VCMY FTYK VRYT NSST EIPE FPIA PEIA LELL MAAN FLDC |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | SIII; TCEB1 |
Positive Sample: | Jurkat,PC-3,MCF7,HepG2,Mouse liver,Mouse lung,Mouse testis,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 12kDa |
Observed MW: | 12kDa |
This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified.
Purification Method: | Affinity purification |
Gene ID: | 6921 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |