The TBXAS1 Polyclonal Antibody (CAB1988) is a valuable tool for researchers studying TBXAS1, an enzyme involved in the synthesis of thromboxane A2, a potent vasoconstrictor and platelet aggregator. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. By specifically targeting the TBXAS1 protein, this antibody allows for the detection and analysis of TBXAS1 expression in various cell types, making it ideal for investigations in cardiovascular, inflammatory, and metabolic disorders.
TBXAS1, also known as thromboxane synthase, plays a critical role in the regulation of platelet aggregation and blood clot formation, making it a key player in the pathogenesis of cardiovascular diseases such as atherosclerosis and thrombosis. Furthermore, dysregulation of TBXAS1 has been implicated in inflammatory conditions and certain cancers, highlighting its potential as a therapeutic target. Insights gained from studying TBXAS1 expression and activity may lead to the development of novel treatments for a range of cardiovascular and inflammatory disorders.
Product Name:
Thromboxane synthase Rabbit Polyclonal Antibody
SKU:
CAB1988
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 355-534 of human Thromboxane synthase (NP_001052.2).
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6916
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Thromboxane synthase Rabbit pAb (CAB1988) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
