null

TBX3/TBX2 Antibody (PACO01593)

SKU:
PACO01593
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS

TBX3/TBX2 Antibody (PACO01593)

The TBX3/TBX2 Antibody (PACO01593) is a specialized tool for researchers studying the TBX3 and TBX2 transcription factors, key regulators of developmental processes and gene expression. This polyclonal antibody, produced through immunization of rabbits, exhibits high specificity and sensitivity for detecting TBX3 and TBX2 proteins in human samples. Validated for use in Western blotting applications, this antibody enables precise identification and quantification of TBX3 and TBX2 expression levels in various cell types.TBX3 and TBX2 are essential transcription factors known to control critical pathways involved in embryonic development, cell differentiation, and tissue regeneration. Dysregulation of these factors has been linked to various diseases, including developmental disorders and cancers.

By targeting TBX3 and TBX2, researchers can gain valuable insights into the mechanisms underlying these conditions and explore potential therapeutic interventions.With its ability to specifically recognize TBX3 and TBX2 proteins, the PACO01593 antibody is a valuable asset for studies in developmental biology, cancer research, and regenerative medicine. By uncovering the roles and functions of TBX3 and TBX2, researchers can advance our understanding of complex biological processes and pave the way for innovative approaches to treating a range of disorders and diseases.

Antibody Name:TBX3/TBX2 Antibody
Antibody SKU:PACO01593
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from the Internal region of human TBX2/3.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:TBX3; T-box transcription factor TBX3; T-box protein 3; TBX2; T-box transcription factor TBX2; T-box protein 2
UniProt Protein Function:TBX3: Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS). UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q24.21

Cellular Component: nucleus

Molecular Function:protein binding; sequence-specific DNA binding

Biological Process: embryonic forelimb morphogenesis; limbic system development; positive regulation of transcription, DNA-dependent; negative regulation of epithelial cell differentiation; palate development; negative regulation of transcription from RNA polymerase II promoter; female genitalia development; forelimb morphogenesis; mammary gland development; determination of anterior/posterior axis, embryo; positive regulation of cell proliferation; male genitalia development; heart looping; skeletal development; luteinizing hormone secretion; blood vessel development; specification of organ position; transcription, DNA-dependent; in utero embryonic development; stem cell maintenance; positive regulation of cell cycle; cell aging; regulation of transcription from RNA polymerase II promoter; organ morphogenesis; mesoderm morphogenesis; follicle-stimulating hormone secretion; embryonic digit morphogenesis; negative regulation of myoblast differentiation; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis

Disease: Ulnar-mammary Syndrome

NCBI Summary:This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:O15119
NCBI GenInfo Identifier:28381401
NCBI Gene ID:6926
NCBI Accession:O15119.4
UniProt Secondary Accession:O15119,Q8TB20, Q9UKF8,
UniProt Related Accession:O15119
Molecular Weight:743
NCBI Full Name:T-box transcription factor TBX3
NCBI Synonym Full Names:T-box 3
NCBI Official Symbol:TBX3  
NCBI Official Synonym Symbols:UMS; XHL; TBX3-ISO  
NCBI Protein Information:T-box transcription factor TBX3; T-box protein 3; bladder cancer related protein XHL
UniProt Protein Name:T-box transcription factor TBX3
Protein Family:T-box transcription factor
UniProt Gene Name:TBX3  
UniProt Entry Name:TBX3_HUMAN

Related Products