The TBX19 Polyclonal Antibody (CAB10481) is a valuable tool for researchers studying TBX19, a transcription factor involved in the development and function of the hypothalamic-pituitary-adrenal (HPA) axis. This antibody, generated in rabbits, exhibits high specificity and sensitivity when detecting TBX19 in human samples, making it ideal for use in Western blot applications.TBX19 plays a crucial role in the regulation of stress response and energy balance, making it an important target for research in endocrinology and neurobiology. Dysregulation of TBX19 has been implicated in various disorders, including Cushing's syndrome and adrenal insufficiency, highlighting the significance of understanding its function.
By utilizing the TBX19 Polyclonal Antibody, researchers can accurately detect and analyze TBX19 expression in different cell types, providing valuable insights into its role in the HPA axis and stress response mechanisms. This antibody is a valuable tool for advancing research in endocrine disorders and identifying potential therapeutic targets for the treatment of related conditions.
Product Name:
TBX19 Rabbit Polyclonal Antibody
SKU:
CAB10481
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 229-448 of human TBX19 (NP_005140.1).
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure.
Purification Method:
Affinity purification
Gene ID:
9095
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and 293T cells transfected with TBX19, using TBX19 Rabbit pAb (CAB10481) at 1:2500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
