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TBX18 Antibody (PACO30298)

SKU:
PACO30298
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

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TBX18 Antibody (PACO30298)

The TBX18 Polyclonal Antibody (PAC030298) is a valuable tool for researchers studying the TBX18 protein, a transcription factor involved in heart development and function. This antibody, raised in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By targeting the TBX18 protein, this antibody enables researchers to detect and analyze TBX18 expression in various cell types, making it well-suited for cardiovascular research and studies on congenital heart defects.

TBX18 plays a crucial role in cardiac development by regulating gene expression and cell differentiation in the heart. Dysregulation of TBX18 has been linked to various cardiovascular disorders, making it a promising therapeutic target for heart disease and heart failure. Understanding the function of TBX18 is essential for developing novel treatments and interventions to improve cardiac health and address congenital heart abnormalities.

Antibody Name:TBX18 Antibody (PACO30298)
Antibody SKU:PACO30298
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Human
Immunogen:Recombinant Human T-box transcription factor TBX18 protein (1-607AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Probable transcriptional regulator involved in developmental processes.
Synonyms:T-box transcription factor TBX18 (T-box protein 18), TBX18
UniProt Protein Function:TBX18: Probable transcriptional regulator involved in developmental processes.
UniProt Protein Details:

Protein type:Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 6q14-q15

Cellular Component: nucleus

Molecular Function:protein binding; protein heterodimerization activity; protein homodimerization activity; transcription factor activity

Biological Process: anterior/posterior axis specification; morphogenesis of embryonic epithelium; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell-cell adhesion; positive regulation of epithelial cell proliferation; sensory perception of sound; smooth muscle cell differentiation; somitogenesis; transcription, DNA-dependent

Disease: Huntington Disease

NCBI Summary:This genes codes for a member of an evolutionarily conserved family of transcription factors that plays a crucial role in embryonic development. The family is characterized by the presence of the DNA-binding T-box domain and is divided into five sub-families based on sequence conservation in this domain. The encoded protein belongs to the vertebrate specific Tbx1 sub-family. The protein acts as a transcriptional repressor by antagonizing transcriptional activators in the T-box family. The protein forms homo- or heterodimers with other transcription factors of the T-box family or other transcription factors. [provided by RefSeq, Nov 2012]
UniProt Code:O95935
NCBI GenInfo Identifier:122937456
NCBI Gene ID:9096
NCBI Accession:NP_001073977.1
UniProt Secondary Accession:O95935,Q7Z6U4, Q9UJI6, A2RU13,
UniProt Related Accession:O95935
Molecular Weight:80.8 kDa
NCBI Full Name:T-box transcription factor TBX18
NCBI Synonym Full Names:T-box 18
NCBI Official Symbol:TBX18  
NCBI Protein Information:T-box transcription factor TBX18
UniProt Protein Name:T-box transcription factor TBX18
Protein Family:T-box transcription factor
UniProt Gene Name:TBX18  
UniProt Entry Name:TBX18_HUMAN

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