TBX18 Antibody (PACO17216)
- SKU:
- PACO17216
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
TBX18 Antibody (PACO17216)
The TBX18 Polyclonal Antibody (PAC017216) is a valuable tool for researchers studying TBX18, a transcription factor involved in various biological processes, including heart development and differentiation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards TBX18 in human samples, making it suitable for Western blot applications. By binding to the TBX18 protein, researchers can analyze its expression and function in different cell types, providing insights into its role in cardiovascular development and disease.TBX18 is a key player in cardiac development, playing critical roles in the formation of the heart chambers and conduction system.
Dysregulation of TBX18 has been associated with congenital heart defects and arrhythmias, highlighting its importance in cardiovascular biology. By studying TBX18 using this antibody, researchers can unravel its molecular mechanisms and potential therapeutic targets for heart-related conditions.Overall, the TBX18 Polyclonal Antibody offers a reliable tool for investigating the functions of TBX18 in cardiac development and disease, paving the way for new insights into cardiovascular biology and potential therapeutic strategies.
| Antibody Name: | TBX18 Antibody (PACO17216) |
| Antibody SKU: | PACO17216 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:10-1:50 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human TBX18 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17216(TBX18 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | This genes codes for a member of an evolutionarily conserved family of transcription factors that plays a crucial role in embryonic development. The family is characterized by the presence of the DNA-binding T-box domain and is divided into five sub-families based on sequence conservation in this domain. The encoded protein belongs to the vertebrate specific Tbx1 sub-family. The protein acts as a transcriptional repressor by antagonizing transcriptional activators in the T-box family. The protein forms homo- or heterodimers with other transcription factors of the T-box family or other transcription factors. |
| Synonyms: | T-box 18 |
| UniProt Protein Function: | TBX18: Probable transcriptional regulator involved in developmental processes. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 6q14-q15 Cellular Component: nucleus Molecular Function:protein binding; protein heterodimerization activity; protein homodimerization activity; transcription factor activity Biological Process: anterior/posterior axis specification; morphogenesis of embryonic epithelium; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell-cell adhesion; positive regulation of epithelial cell proliferation; sensory perception of sound; smooth muscle cell differentiation; somitogenesis; transcription, DNA-dependent Disease: Huntington Disease |
| NCBI Summary: | This genes codes for a member of an evolutionarily conserved family of transcription factors that plays a crucial role in embryonic development. The family is characterized by the presence of the DNA-binding T-box domain and is divided into five sub-families based on sequence conservation in this domain. The encoded protein belongs to the vertebrate specific Tbx1 sub-family. The protein acts as a transcriptional repressor by antagonizing transcriptional activators in the T-box family. The protein forms homo- or heterodimers with other transcription factors of the T-box family or other transcription factors. [provided by RefSeq, Nov 2012] |
| UniProt Code: | O95935 |
| NCBI GenInfo Identifier: | 122937456 |
| NCBI Gene ID: | 9096 |
| NCBI Accession: | NP_001073977.1 |
| UniProt Secondary Accession: | O95935,Q7Z6U4, Q9UJI6, A2RU13, |
| UniProt Related Accession: | O95935 |
| Molecular Weight: | 80.8 kDa |
| NCBI Full Name: | T-box transcription factor TBX18 |
| NCBI Synonym Full Names: | T-box 18 |
| NCBI Official Symbol: | TBX18Â Â |
| NCBI Protein Information: | T-box transcription factor TBX18 |
| UniProt Protein Name: | T-box transcription factor TBX18 |
| Protein Family: | T-box transcription factor |
| UniProt Gene Name: | TBX18Â Â |
| UniProt Entry Name: | TBX18_HUMAN |
| Antibodies | ELISA Kits |
| TBX18 Antibody (PACO05688) | TBX18 Transcription Factor Activity Assay |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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TBX18 Transcription Factor Activity Assay
