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TBX18 Antibody (PACO05688)

SKU:
PACO05688
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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TBX18 Antibody (PACO05688)

The TBX18 polyclonal antibody (PACO05688) is a valuable tool for researchers studying the transcription factor TBX18, which plays a crucial role in development and organogenesis. This antibody, raised in rabbits, has high reactivity with human samples and has been validated for use in various applications, including immunohistochemistry and Western blotting.TBX18 is known for its involvement in the development of various organs, including the heart, bladder, and lungs. Dysregulation of TBX18 has been linked to congenital defects and diseases affecting these organs, making it a target of interest in regenerative medicine and developmental biology research.

By utilizing the TBX18 polyclonal antibody, researchers can gain valuable insights into the expression and function of TBX18 in different cell types and tissues, contributing to our understanding of organ development and disease pathology. This antibody is an essential tool for studies investigating the role of TBX18 in various biological processes, making it a valuable asset in the fields of molecular biology and developmental genetics.

Antibody Name:TBX18 Antibody (PACO05688)
Antibody SKU:PACO05688
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:20000, WB:1:500-1:2000
Species Reactivity:Human, Mouse, Rat
Immunogen:Synthesized peptide derived from the Internal region of human TBX18.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:TBX18; T-box transcription factor TBX18; T-box protein 18
UniProt Protein Function:TBX18: Probable transcriptional regulator involved in developmental processes.
UniProt Protein Details:

Protein type:Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 6q14-q15

Cellular Component: nucleus

Molecular Function:protein binding; protein heterodimerization activity; protein homodimerization activity; transcription factor activity

Biological Process: anterior/posterior axis specification; morphogenesis of embryonic epithelium; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell-cell adhesion; positive regulation of epithelial cell proliferation; sensory perception of sound; smooth muscle cell differentiation; somitogenesis; transcription, DNA-dependent

Disease: Huntington Disease

NCBI Summary:This genes codes for a member of an evolutionarily conserved family of transcription factors that plays a crucial role in embryonic development. The family is characterized by the presence of the DNA-binding T-box domain and is divided into five sub-families based on sequence conservation in this domain. The encoded protein belongs to the vertebrate specific Tbx1 sub-family. The protein acts as a transcriptional repressor by antagonizing transcriptional activators in the T-box family. The protein forms homo- or heterodimers with other transcription factors of the T-box family or other transcription factors. [provided by RefSeq, Nov 2012]
UniProt Code:O95935
NCBI GenInfo Identifier:122937456
NCBI Gene ID:9096
NCBI Accession:NP_001073977.1
UniProt Secondary Accession:O95935,Q7Z6U4, Q9UJI6, A2RU13,
UniProt Related Accession:O95935
Molecular Weight:80.8 kDa
NCBI Full Name:T-box transcription factor TBX18
NCBI Synonym Full Names:T-box 18
NCBI Official Symbol:TBX18  
NCBI Protein Information:T-box transcription factor TBX18
UniProt Protein Name:T-box transcription factor TBX18
Protein Family:T-box transcription factor
UniProt Gene Name:TBX18  
UniProt Entry Name:TBX18_HUMAN

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