TBX15/TBX18 Antibody (PACO23730)
- SKU:
- PACO23730
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
TBX15/TBX18 Antibody (PACO23730)
The TBX15/TBX18 Antibody (PAC023730) is a valuable tool for researchers studying the TBX15 and TBX18 proteins, which are involved in developmental processes such as organogenesis and cell differentiation. This polyclonal antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.TBX15 and TBX18 are transcription factors that play essential roles in the development of various organs, including the heart and lungs. Dysregulation of these proteins has been implicated in congenital defects and disease states, making them important targets for research in developmental biology and regenerative medicine.
By using the TBX15/TBX18 Antibody, researchers can detect and analyze the expression levels of these proteins in different cell types, providing valuable insights into their functions and potential roles in disease pathology. This antibody is a valuable tool for advancing our understanding of developmental processes and identifying potential therapeutic targets for various conditions.
| Antibody Name: | TBX15/TBX18 Antibody (PACO23730) |
| Antibody SKU: | PACO23730 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from internal of human TBX15/18. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from HeLa cells, HUVEC cells and Jurkat cells, using TBX15/18 antibody. |
 | Immunofluorescence analysis of HeLa cells, using TBX15/18 antibody. |
 | Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using TBX15/18 antibody. |
| Background: | Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes By similarity. |
| Synonyms: | T-box transcription factor TBX15; T-box protein 15; TBX15; TBX14; T-box transcription factor TBX18 |
| UniProt Protein Function: | TBX15: Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes. Defects in TBX15 are the cause of Cousin syndrome (COUSS); also known as craniofacial dysmorphism, hypoplasia of scapula and pelvis, and short stature. Cousin syndrome is defined as pelviscapular dysplasia with epiphyseal abnormalities, congenital dwarfism and facial dysmorphy (frontal bossing, hypertelorism, narrow palpebral fissures, deep set globes, strabismus, low-set posteriory rotated and unusually formed external ears, dysplasia of conchae, small chin, short neck with redundant skin folds, and a low hairline). Intelligence may vary from normal to moderately impaired. Radiographic features comprise aplasia of the body of the scapula, hypoplasia of the iliac bone, humeroradial synosthosis, dislocation of the femoral heads, and moderate brachydactyly. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 1p11.1 Molecular Function:protein binding Disease: Cousin Syndrome |
| NCBI Summary: | This gene belongs to the T-box family of genes, which encode a phylogenetically conserved family of transcription factors that regulate a variety of developmental processes. All these genes contain a common T-box DNA-binding domain. Mutations in this gene are associated with Cousin syndrome.[provided by RefSeq, Oct 2009] |
| UniProt Code: | Q96SF7 |
| NCBI GenInfo Identifier: | 59803103 |
| NCBI Gene ID: | 6913 |
| NCBI Accession: | Q96SF7.2 |
| UniProt Secondary Accession: | Q96SF7,Q08E76, Q5JT54, Q5T9S7, |
| UniProt Related Accession: | Q96SF7 |
| Molecular Weight: | 54,671 Da |
| NCBI Full Name: | T-box transcription factor TBX15 |
| NCBI Synonym Full Names: | T-box 15 |
| NCBI Official Symbol: | TBX15Â Â |
| NCBI Official Synonym Symbols: | TBX14Â Â |
| NCBI Protein Information: | T-box transcription factor TBX15 |
| UniProt Protein Name: | T-box transcription factor TBX15 |
| UniProt Synonym Protein Names: | T-box transcription factor TBX14; T-box protein 14 |
| Protein Family: | T-box transcription factor |
| UniProt Gene Name: | TBX15Â Â |
| UniProt Entry Name: | TBX15_HUMAN |
Related Products
TBX18/TBX15 Antibody (PACO01591)
TBX18 Antibody (PACO17216)
Tbx15 Antibody (PACO30294)
TBX18 Antibody (PACO22644)
TBX15 Antibody (PACO38766)
TBX18 Antibody (PACO17217)
TBX18 Antibody (PACO30298)
TBX18 Antibody (PACO05688)
