The TBX10 Polyclonal Antibody (PAC021698) is a vital tool for researchers studying the TBX10 protein, a transcription factor essential for proper cardiac development. This antibody, generated in rabbits, demonstrates high specificity towards human samples and has been validated for use in Western blot applications. By binding to the TBX10 protein, this antibody enables accurate detection and analysis in various cell types, making it an ideal choice for investigations into heart development and cardiovascular diseases.
TBX10 is known for its crucial role in heart morphogenesis, specifically in the formation of the cardiac outflow tract and development of the ventricles. Dysregulation of TBX10 has been linked to congenital heart defects and other cardiac abnormalities, making it a valuable target for research in cardiovascular medicine. Understanding the functions and mechanisms of TBX10 is essential for advancing knowledge of heart development and potentially uncovering new therapeutic strategies for heart-related disorders.
Antibody Name:
TBX10 Antibody (PACO21698)
Antibody SKU:
PACO21698
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human TBX10.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HT-29 cells, using TBX10 antibody.
Background:
Probable transcriptional regulator involved in developmental processes. The MGC Project Team, Genome Res. 14:2121-2127(2004).
Synonyms:
T-box transcription factor TBX10; T-box protein 10; TBX10; TBX7;
UniProt Protein Function:
TBX10: Probable transcriptional regulator involved in developmental processes.
Biological Process: anatomical structure morphogenesis; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent
NCBI Summary:
This gene encodes a member of the T-box family of transcription factors. These transcription factors share a DNA-binding domain called the T-box, and play a role in several developmental processes including early embryonic cell fate and organogenesis. The encoded protein is a member of the T-box 1 subfamily. Mutations in this gene are thought to be a cause of isolated cleft lip with or without cleft palate. [provided by RefSeq, Nov 2010]
