The TBX10 Antibody (PAC017218) is a vital tool for research involving the TBX10 protein, a transcription factor known for its role in the development and differentiation of various tissues, notably the heart and lungs. This polyclonal antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for studies in developmental biology and cardiovascular research.TBX10 is a key regulator of gene expression, playing a crucial role in embryonic development and tissue formation. It is particularly important in the specification of cardiopulmonary progenitor cells and the patterning of the heart and lung during embryogenesis.
Dysregulation of TBX10 has been linked to congenital heart defects and other developmental anomalies, making it a target of interest in understanding these conditions.The TBX10 Antibody is validated for use in various applications, including Western blot and immunohistochemistry, allowing for the detection and analysis of TBX10 expression in different cell types and tissues. By targeting TBX10, researchers can gain insights into the molecular mechanisms underlying heart and lung development, paving the way for potential therapeutic interventions in congenital diseases and other disorders related to TBX10 dysregulation.
Antibody Name:
TBX10 Antibody (PACO17218)
Antibody SKU:
PACO17218
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Fusion protein of human TBX10
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO17218(TBX10 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of the T-box family of transcription factors. These transcription factors share a DNA-binding domain called the T-box, and play a role in several developmental processes including early embryonic cell fate and organogenesis. The encoded protein is a member of the T-box 1 subfamily. Mutations in this gene are thought to be a cause of isolated cleft lip with or without cleft palate.
Synonyms:
T-box 10
UniProt Protein Function:
TBX10: Probable transcriptional regulator involved in developmental processes.
Biological Process: anatomical structure morphogenesis; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent
NCBI Summary:
This gene encodes a member of the T-box family of transcription factors. These transcription factors share a DNA-binding domain called the T-box, and play a role in several developmental processes including early embryonic cell fate and organogenesis. The encoded protein is a member of the T-box 1 subfamily. Mutations in this gene are thought to be a cause of isolated cleft lip with or without cleft palate. [provided by RefSeq, Nov 2010]
