TBL1XR1 Rabbit Polyclonal Antibody (CAB7834)
- SKU:
- CAB7834
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | TBL1XR1 Rabbit Polyclonal Antibody |
SKU: | CAB7834 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human TBL1XR1 (NP_078941.2). |
Sequence: | MSIS SDEV NFLV YRYL QESG FSHS AFTF GIES HISQ SNIN GALV PPAA LISI IQKG LQYV EAEV SINE DGTL FDGR PIES LSLI DAVM PDVV QTRQ QAYR DKLA QQQA AAAA AAAA AASQ QGSA KNGE NTAN GEEN GAHT IANN HTDM MEVD GDVE IPPN KAVV LRGH ESEV FICA WNPV |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | C21; DC42; IRA1; MRD41; TBLR1; TBL1XR1 |
Positive Sample: | Jurkat,HepG2,NCI-H460,THP-1,Mouse brain,Mouse spleen |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 56kDa |
Observed MW: | 60kDa |
This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors.
Purification Method: | Affinity purification |
Gene ID: | 79718 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |