The TBL1XR1 Polyclonal Antibody (CAB7834) is designed for research involving TBL1XR1, a key protein involved in gene regulation and transcriptional control. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the TBL1XR1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it a valuable tool for studies in molecular biology and cancer research.TBL1XR1 is known to interact with various transcription factors and co-repressors, playing a critical role in the regulation of gene expression.
Dysregulation of TBL1XR1 has been implicated in various diseases, including cancer and neurodevelopmental disorders, making it a promising target for therapeutic interventions. Understanding the function of TBL1XR1 is essential for unraveling its role in disease pathogenesis and developing targeted treatments to modulate its activity for therapeutic benefit.
Product Name:
TBL1XR1 Rabbit Polyclonal Antibody
SKU:
CAB7834
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human TBL1XR1 (NP_078941.2).
This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors.
Purification Method:
Affinity purification
Gene ID:
79718
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TBL1XR1 antibody (CAB7834) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
