The TBL1XR1 Polyclonal Antibody (CAB13438) is a valuable tool for researchers studying the TBL1XR1 protein, which is involved in various cellular functions including gene regulation and transcriptional control. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting TBL1XR1 in human samples, making it suitable for use in Western blot experiments.TBL1XR1 is a crucial component of the transcriptional corepressor complex, playing a key role in regulating gene expression and chromatin remodeling. Dysregulation of TBL1XR1 has been implicated in various diseases, including cancer and developmental disorders.
By targeting TBL1XR1 with this polyclonal antibody, researchers can gain insights into its function and potential therapeutic implications.With its ability to specifically bind to TBL1XR1, this polyclonal antibody enables researchers to investigate the role of TBL1XR1 in diverse cellular processes and pathological conditions. Its versatility and reliability make it an essential tool for studies in molecular biology, oncology, and developmental biology.
Product Name:
TBL1XR1 Rabbit Polyclonal Antibody
SKU:
CAB13438
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 120-170 of human TBL1XR1 (NP_078941.2).
This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors.
Purification Method:
Affinity purification
Gene ID:
79718
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of K-562 cells, using TBL1XR1 antibody (CAB13438) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
