The TBKBP1 Polyclonal Antibody (PACO62387) is a valuable tool for researchers studying TBKBP1, a protein involved in immune signaling pathways. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the TBKBP1 protein, this antibody enables precise detection and analysis in various cell types, making it an essential component for studies in immunology and cancer research.TBKBP1, also known as TANK-binding kinase 1-binding protein 1, plays a crucial role in immune response regulation by modulating signaling cascades involved in inflammation and antiviral defense.
Its function in immune signaling pathways makes it a promising target for research into diseases such as cancer, viral infections, and autoimmune disorders. Understanding the role of TBKBP1 in immune regulation is vital for developing targeted therapies that manipulate immune responses in different disease contexts.
Antibody Name:
TBKBP1 Antibody (PACO62387)
Antibody SKU:
PACO62387
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human TANK-binding kinase 1-binding protein 1 protein (327-427AA)
Immunofluorescence staining of Hela cells with PACO62387 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.
Synonyms:
TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1), TBKBP1, KIAA0775 SINTBAD
UniProt Protein Function:
TBKBP1: Adapter protein which constitutively binds TBK1 and IKBKE and may play a role in antiviral innate immunity. Homodimer. May form a heterodimer with NAP1. Interacts with TKB1 and IKBKE. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 17q21.32Molecular Function: protein bindingBiological Process: innate immune response
UniProt Protein Details:
NCBI Summary:
TBKBP1 is an adaptor protein that binds to TBK1 (MIM 604834) and is part of the interaction network in the TNF (MIM 191160)/NFKB (see MIM 164011) pathway (Bouwmeester et al., 2004 [PubMed 14743216]).[supplied by OMIM, Mar 2008]
