The TBK1 Polyclonal Antibody (CAB2573) is a powerful tool for researchers studying TBK1, a key player in the regulation of cellular immune responses and inflammation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the TBK1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for studies in immunology, cancer research, and beyond.TBK1, also known as TANK-binding kinase 1, is a crucial mediator of innate immune responses, playing a vital role in the activation of interferon-regulatory factors and the induction of type I interferons.
Dysregulation of TBK1 has been implicated in various diseases, including cancer, autoimmune disorders, and infectious diseases. Investigating TBK1 activity is essential for developing targeted therapies that modulate immune responses and combat these conditions effectively.By using the TBK1 Polyclonal Antibody (CAB2573), researchers can delve deeper into the intricate mechanisms governing immune responses and inflammation, opening up new possibilities for therapeutic interventions and advancing our understanding of complex diseases.
Product Name:
TBK1/NAK Rabbit Polyclonal Antibody
SKU:
CAB2573
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 500-600 of human TBK1/NAK (NP_037386.1).
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein is also an important kinase for antiviral innate immunity response.
Purification Method:
Affinity purification
Gene ID:
29110
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse lung, using TBK1/NAK Rabbit pAb (CAB2573) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
