The TBC1D24 Polyclonal Antibody (PAC04722) is a valuable tool for research involving the TBC1D24 protein, a member of the TBC (Tre-2/Bub2/Cdc16) domain-containing family. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.TBC1D24 is known to play a role in various cellular processes, including endosomal trafficking, autophagy, and neuronal function. Dysregulation of TBC1D24 has been linked to neurological disorders such as epilepsy and intellectual disabilities.
Therefore, studying the expression and function of TBC1D24 is important for understanding its involvement in disease pathology.This antibody binds specifically to the TBC1D24 protein, allowing for the detection and analysis of TBC1D24 in different cell types. By utilizing this antibody in your research, you can gain valuable insights into the function of TBC1D24 and its potential role in neurological disorders. This makes the TBC1D24 Polyclonal Antibody a valuable asset for researchers in the fields of neuroscience and cell biology.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO47222 at dilution of 1:100.
Immunofluorescent analysis of Hela cells using PACO47222 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO47222 at dilution of 1:100.
Background:
May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function.
Synonyms:
TBC1 domain family member 24, TBC1D24, KIAA1171
UniProt Protein Function:
TBC1D24: a putative GTPase activating protein for Rab family protein(s).Protein type: GAPs; Cell development/differentiation; GAPs, RabChromosomal Location of Human Ortholog: 16p13.3Cellular Component: cytoplasm; neuromuscular junction; terminal buttonMolecular Function: GTPase activator activity; protein bindingBiological Process: neurite development; positive regulation of GTPase activityDisease: Deafness, Autosomal Dominant 65; Deafness, Autosomal Recessive 86
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein with a conserved domain, referred to as the TBC domain, characteristic of proteins which interact with GTPases. TBC domain proteins may serve as GTPase-activating proteins for a particular group of GTPases, the Rab (Ras-related proteins in brain) small GTPases which are involved in the regulation of membrane trafficking. Mutations in this gene are associated with familial infantile myoclonic epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]
