The TBC1D22A Polyclonal Antibody (PAC017210) is a valuable tool for researchers studying TBC1D22A, a protein involved in cellular functions related to intracellular trafficking and signal transduction. This antibody, produced in rabbits, specifically recognizes TBC1D22A in human samples and is suitable for Western blot applications. By binding to TBC1D22A, this antibody enables the detection and analysis of this protein in a variety of cell types, making it an essential reagent for studies in molecular biology and cell signaling.TBC1D22A is known for its role in regulating membrane trafficking pathways and cellular signaling processes, impacting crucial cellular functions such as cell growth, division, and communication.
Research on TBC1D22A is key to understanding its involvement in diseases like cancer, neurodegenerative disorders, and metabolic conditions. By elucidating the functions and interactions of TBC1D22A, researchers can uncover potential therapeutic targets and pathways for intervention in these diseases.In summary, the TBC1D22A Polyclonal Antibody (PAC017210) is a reliable tool for investigating the role of TBC1D22A in cellular processes and disease development. Its high specificity and reactivity with human samples make it an essential resource for research in cell biology, molecular biology, and disease mechanisms.
Antibody Name:
TBC1D22A Antibody (PACO17210)
Antibody SKU:
PACO17210
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human TBC1D22A
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17210(TBC1D22A Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:
TBC1D22A (TBC1 domain family, member 22A), also known as C22orf4, is a 517 amino acid, protein that contains one Rab-GAP TBC domain and is thought to function as a GTPase-activating protein for Rab family members. Multiple isoforms of TBC1D22A exist due to alternative splicing events. The gene encoding TBC1D22A maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, neurofibromatosis type 2, autism and schizophrenia. Additionally, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia chromosome and the subsequent production of the novel fusion protein BCR-Abl, a potent cell proliferation activator found in several types of leukemias.
Synonyms:
TBC1 domain family, member 22A
UniProt Protein Function:
TBC1D22A: May act as a GTPase-activating protein for Rab family protein(s). 3 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs; GAPs, RabChromosomal Location of Human Ortholog: 22q13.3Cellular Component: endomembrane system; intracellularMolecular Function: GTPase activator activity; protein binding; protein homodimerization activity; Rab GTPase bindingBiological Process: intracellular protein transport; regulation of vesicle fusion
