The TBC1D20 Polyclonal Antibody (PACO39270) is designed for research involving TBC1D20, a protein involved in regulating cellular processes, specifically in the context of cellular trafficking and signaling pathways. The antibody, raised in rabbits, is highly specific and sensitive for detecting TBC1D20 in human samples, making it ideal for use in Western blot applications. It binds specifically to the TBC1D20 protein, enabling researchers to study its function and role in various cellular processes.TBC1D20 is a key player in intracellular trafficking and signaling, making it a crucial target for research in understanding cellular communication and regulation. Its involvement in these processes suggests potential implications in diseases such as cancer, neurodegenerative disorders, and metabolic conditions.
Investigating the function of TBC1D20 can provide valuable insights into the mechanisms underlying these diseases and may uncover potential therapeutic targets for intervention.Overall, the TBC1D20 Polyclonal Antibody is a valuable tool for researchers studying cellular trafficking and signaling pathways, offering high specificity and sensitivity for detecting TBC1D20 in human samples. Its use in Western blot applications allows for detailed analysis of TBC1D20 protein levels, shedding light on its role in various cellular processes and potential implications in disease.
Western Blot. Positive WB detected in: Mouse brain tissue, Mouse stomach tissue. All lanes: TBC1D20 antibody at 4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 46, 20, 49 kDa. Observed band size: 46 kDa.
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO39270 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO39270 at dilution of 1:100.
Background:
GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude.
Synonyms:
TBC1 domain family member 20, TBC1D20, C20orf140
UniProt Protein Function:
TBC1D20: May act as a GTPase-activating protein for Rab family protein(s). 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; GAPs; Membrane protein, multi-pass; GAPs, RabChromosomal Location of Human Ortholog: 20p13Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; integral to Golgi membrane; nuclear membraneMolecular Function: GTPase activator activity; protein binding; Rab GTPase bindingBiological Process: COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; Golgi organization and biogenesis; positive regulation of GTPase activity; positive regulation of viral protein levels in host cell; virus assemblyDisease: Warburg Micro Syndrome 4
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein that belongs to a family of GTPase activator proteins of Rab-like small GTPases. The encoded protein and its cognate GTPase, Rab1, bind the nonstructural protein 5A (NS5A) of the hepatitis C virus (HCV) to mediate viral replication. Depletion of this protein inhibits replication of the virus and HCV infection. Mutations in this gene are associated with Warburg micro syndrome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
