The TAX1BP3 Polyclonal Antibody (CAB8750) is a valuable tool for researchers studying the TAX1BP3 protein, which plays a key role in various cellular processes, including autophagy and immune response regulation. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications.TAX1BP3 is a critical regulator of autophagy, a process essential for maintaining cellular homeostasis by removing damaged organelles and proteins. Dysregulation of autophagy has been linked to various diseases, including cancer and neurodegenerative disorders, highlighting the importance of studying proteins like TAX1BP3.
This antibody binds specifically to TAX1BP3, enabling researchers to detect and analyze its expression in different cell types, aiding in a better understanding of its function.With its ability to target TAX1BP3, this polyclonal antibody is a valuable tool for researchers working in the fields of cellular biology, immunology, and cancer research. By facilitating the investigation of TAX1BP3's role in autophagy and immune regulation, this antibody opens up new avenues for studying and potentially targeting this protein for therapeutic purposes.
Product Name:
TAX1BP3 Rabbit Polyclonal Antibody
SKU:
CAB8750
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-124 of human TAX1BP3 (NP_055419.1).
This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying potassium channel 2.3 (Kir2.3). To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
30851
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TAX1BP3 Rabbit pAb (CAB8750) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
