Tau Antibodies, Proteins & ELISA Kits

Tau protein is encoded by the MAPT gene (microtubule-associated Tau gene) and it is expressed in the CNS (central nervous system) and the PNS (peripheral nervous system). Tau protein plays a role in axonal transport, stabilization of microtubules and tubulin polymerization into microtubules.

There have been many different tau alterations observed in neurodegenerative disorders. At the gene level there are mutations which can lead to rare familial dementia. At the mRNA level there are alterations in alternative splicing which results in abnormal forms of tau isoforms. Lastly, at the protein level there is abnormal hyperphosphorylation which causes aggregation of abnormal tau (p-tau). This altered phosphorylation results in a loss in microtubule stability and alterations in cellular integrity and cytoskeletal maintenance.

Tauopathies are a set of neurodegenerative disorders which are associated with this aggregation of abnormal tau. Some examples of tauopathies are Alzheimer’s disease, corticobasal syndrome and progressive supranuclear palsy. When tau inclusions form in the brain during tauopathies, abnormal tau leaks into the CSF which can be later quantified. The biochemical characterization of tau inclusions has allowed for an improved diagnosis of the aforementioned neurodegenerative diseases and it has shown to have potential as a diagnostic biomarker.

Assay Genie has a variety of extensively tested ELISA kits which may aid in examining the full extent of how useful tau protein is as a biomarker for neurodegenerative disorders.

We extensively validate our ELISA kits and endeavor to provide each kit with the following data: Linearity, Range, Sensitivity, Spike-Recovery, CV% and Standard Curve.

Assay Genie has a wide variety of Cell-Based ELISA Kits which can be used to detect different levels of tau protein.

Assay Genie has antibodies available which can be used to analyze tau as a biomarker for neurodegenerative diseases.

Assay Genie has a range of tau recombinant proteins which can be used for research purposes.