The TAS2R8 Polyclonal Antibody (PACO01575) is a valuable tool for researchers studying TAS2R8, a bitter taste receptor involved in taste perception and immune regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the TAS2R8 protein, this antibody allows for the detection and analysis of TAS2R8 in a variety of cell types, making it well-suited for studies in taste biology and immunology.TAS2R8, a member of the TAS2R family of taste receptors, is known for its role in detecting bitter compounds and triggering aversive responses to potentially harmful substances.
Recent research has also highlighted its involvement in immune responses, suggesting a potential link between taste perception and immune regulation. Studies on TAS2R8 could provide important insights into the interplay between taste perception, immune function, and overall health, with implications for understanding diseases related to taste and immune dysfunction. By utilizing the TAS2R8 Polyclonal Antibody, researchers can explore the functions and mechanisms of TAS2R8 in various physiological contexts, paving the way for innovative discoveries in taste biology and immunology.
Antibody Name:
TAS2R8 Antibody
Antibody SKU:
PACO01575
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IF
Recommended Dilutions:
WB:1:500-1:2000, IF:1:200-1:1000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human T2R8.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
TAS2R8; Taste receptor type 2 member 8; T2R8; Taste receptor family B member 5; TRB5
UniProt Protein Function:
TAS2R8: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. Belongs to the G-protein coupled receptor T2R family.Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, T2R family; Receptor, GPCRChromosomal Location of Human Ortholog: 12p13Cellular Component: integral to membrane; plasma membraneMolecular Function: bitter taste receptor activity; taste receptor activityBiological Process: G-protein coupled receptor protein signaling pathway; detection of chemical stimulus involved in sensory perception of bitter taste
UniProt Protein Details:
NCBI Summary:
This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]
