Anti-TARS2 Antibody (CAB12853)
- SKU:
- CAB12853
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Anti-TARS2 Antibody (CAB12853)
The TARS2 Polyclonal Antibody (CAB12853) is a valuable tool for researchers studying TARS2, a mitochondrial enzyme involved in protein translation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the TARS2 protein, this antibody allows for the detection and analysis of TARS2 in various cell types, making it ideal for studies related to mitochondrial function and protein synthesis.TARS2 is essential for the charging of tRNA molecules with the amino acid threonine, a crucial step in the protein synthesis process.
Dysregulation of TARS2 has been linked to various diseases, including neurodegenerative disorders and mitochondrial dysfunction. Therefore, research on TARS2 is vital for understanding cellular metabolism and the development of potential therapies targeting these conditions.Overall, the TARS2 Polyclonal Antibody (CAB12853) provides researchers with a reliable tool for investigating the role of TARS2 in health and disease, offering insights that may lead to new advancements in the field of molecular biology and medicine.
| Antibody Name: | Anti-TARS2 Antibody |
| Antibody SKU: | CAB12853 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-400 of human TARS2 (NP_079426.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | LO2, U-87MG, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-400 of human TARS2 (NP_079426.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VNGE PYDL ERPL ETDS DLRF LTFD SPEG KAVF WHSS THVL GAAA EQFL GAVL CRGP STEY GFYH DFFL GKER TIRG SELP VLER ICQE LTAA ARPF RRLE ASRD QLRQ LFKD NPFK LHLI EEKV TGPT ATVY GCGT LVDL CQGP HLRH TGQI GGLK LLSN SSSL WRSS GAPE TLQR VSGI SFPT TELL RVWE AWRE EAEL RDHR RIGK EQEL FFFH ELSP GSCF FLPR GTRV YNAL VAFI RAEY AHRG FSEV KTPT LFST KLWE QSGH WEHY QEDM FAVQ PPGS DRPP SSQS DDST RHIT D |
| Gene ID: | 80222 |
| Uniprot: | Q9BW92 |
| Cellular Location: | Mitochondrion matrix |
| Calculated MW: | 66kDa/81kDa |
| Observed MW: | 81kDa |
| Synonyms: | TARS2, COXPD21, TARSL1, thrRS |
| Background: | This gene encodes a member of the class-II aminoacyl-tRNA synthetase family. The encoded protein is a mitochondrial aminoacyl-tRNA synthetase. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 4. |
| UniProt Protein Function: | TARS2: Belongs to the class-II aminoacyl-tRNA synthetase family. |
| UniProt Protein Details: | Protein type:Aminoacyl-tRNA synthetase; EC 6.1.1.3; Ligase; Mitochondrial; Translation; Translation regulation Chromosomal Location of Human Ortholog: 1q21.2 Cellular Component: mitochondrion Molecular Function:protein homodimerization activity; threonine-tRNA ligase activity Disease: Combined Oxidative Phosphorylation Deficiency 21 |
| NCBI Summary: | This gene encodes a member of the class-II aminoacyl-tRNA synthetase family. The encoded protein is a mitochondrial aminoacyl-tRNA synthetase. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 4. [provided by RefSeq, Dec 2012] |
| UniProt Code: | Q9BW92 |
| NCBI GenInfo Identifier: | 74752395 |
| NCBI Gene ID: | 80222 |
| NCBI Accession: | Q9BW92.1 |
| UniProt Secondary Accession: | Q9BW92,Q53GW7, Q96I50, Q9H9V2, |
| UniProt Related Accession: | Q9BW92 |
| Molecular Weight: | 81kDa |
| NCBI Full Name: | Threonine--tRNA ligase, mitochondrial |
| NCBI Synonym Full Names: | threonyl-tRNA synthetase 2, mitochondrial (putative) |
| NCBI Official Symbol: | TARS2Â Â |
| NCBI Official Synonym Symbols: | thrRS; TARSL1; COXPD21Â Â |
| NCBI Protein Information: | threonine--tRNA ligase, mitochondrial |
| UniProt Protein Name: | Threonine--tRNA ligase, mitochondrial |
| UniProt Synonym Protein Names: | Threonyl-tRNA synthetase; ThrRS; Threonyl-tRNA synthetase-like 1 |
| UniProt Gene Name: | TARS2Â Â |
 | Western blot analysis of extracts of various cell lines, using TARS2 antibody (CAB12853) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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