The TDP-43 (TARDBP) Rabbit Polyclonal Antibody (CAB17114) offered by AssayGenie is a valuable tool for researchers studying TDP-43, a nuclear protein involved in RNA processing and regulation of gene expression. This antibody, raised in rabbits, exhibits high specificity and reactivity with human samples, making it suitable for use in a variety of research applications, including Western blotting.TDP-43 plays a crucial role in RNA metabolism and has been implicated in neurodegenerative diseases such as ALS and frontotemporal lobar degeneration. The TDP-43 Rabbit Polyclonal Antibody binds specifically to the TDP-43 protein, allowing for precise detection and analysis in various cell types.
Its utility in immunology and neurobiology research makes it a valuable tool for investigating the role of TDP-43 in disease pathogenesis and potential therapeutic interventions.By using the TDP-43 Rabbit Polyclonal Antibody (CAB17114), researchers can gain valuable insights into the function and regulation of TDP-43, advancing our understanding of its role in disease development and progression. This antibody is an essential resource for studies focused on elucidating the molecular mechanisms underlying neurodegenerative disorders and RNA processing dysregulation.
Antibody Name:
Anti-TARDBP Antibody
Antibody SKU:
CAB17114
Antibody Size:
20uL, 50uL, 100uL
Application:
WB IHC IF
Reactivity:
Human, Mouse, Rat
Host Species:
Rabbit
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human TARDBP (NP_031401.1).
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
NCBI Summary:
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]
