The TDP-43 Polyclonal Antibody (CAB13405) is a valuable tool for research involving TAR DNA-binding protein 43 (TDP-43), a nuclear protein that plays a critical role in RNA processing and gene regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications including Western blot and immunohistochemistry.TDP-43 is associated with several neurodegenerative diseases, including Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD), making it a key target for studying the pathology and mechanisms of these disorders.
The TDP-43 Polyclonal Antibody binds specifically to TDP-43 protein, allowing for detection and analysis in different cell types and tissues, making it an essential tool for researchers in the fields of neuroscience and neurobiology.Understanding the function and regulation of TDP-43 is crucial for advancing our knowledge of neurodegenerative diseases and developing targeted therapies for patients. The TDP-43 Polyclonal Antibody provides researchers with a reliable and accurate tool for investigating the role of TDP-43 in disease pathogenesis and potential therapeutic interventions.
Product Name:
TDP-43/TARDB Rabbit Polyclonal Antibody
SKU:
CAB13405
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human TDP-43/TARDBP (NP_031401.1).
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
Purification Method:
Affinity purification
Gene ID:
23435
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using TDP-43/TARDB Rabbit pAb (CAB13405) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
