TAP2 Rabbit Polyclonal Antibody (CAB1610)
- SKU:
- CAB1610
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | TAP2 Rabbit Polyclonal Antibody |
SKU: | CAB1610 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 450-686 of human TAP2 (NP_001276972.1). |
Sequence: | QPNL PSPG TLAP TTLQ GVVK FQDV SFAY PNRP DRPV LKGL TFTL RPGE VTAL VGPN GSGK STVA ALLQ NLYQ PTGG QVLL DEKP ISQY EHCY LHSQ VVSV GQEP VLFS GSVR NNIA YGLQ SCED DKVM AAAQ AAHA DDFI QEME HGIY TDVG EKGS QLAA GQKQ RLAI ARAL VRDP RVLI LDEA TSAL DVQC EQAL QDWN SRGD RTVL VIAH RLQT VQRA HQIL VLQE GKLQ KLAQ L |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | APT2; PSF2; ABC18; ABCB3; PSF-2; RING11; D6S217E; TAP2 |
Positive Sample: | Rat spleen |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Multi-pass membrane protein. |
Calculated MW: | 76kDa |
Observed MW: | 75kDa |
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.
Purification Method: | Affinity purification |
Gene ID: | 6891 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3. |