The TAP2 Polyclonal Antibody (CAB1610) is a valuable tool for researchers studying the TAP2 protein, an essential component of the antigen processing and presentation pathway in the immune system. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the TAP2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in immunology and infectious diseases research.TAP2, also known as transporter associated with antigen processing 2, plays a crucial role in the transport of antigenic peptides from the cytoplasm into the endoplasmic reticulum for presentation to T cells.
Understanding the function of TAP2 is essential for unraveling the mechanisms of immune responses and identifying potential targets for immunotherapy. Research involving TAP2 may provide insights into autoimmune diseases, viral infections, and cancer immunology, ultimately leading to the development of novel therapies and vaccines.
Product Name:
TAP2 Rabbit Polyclonal Antibody
SKU:
CAB1610
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 450-686 of human TAP2 (NP_001276972.1).
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.
Purification Method:
Affinity purification
Gene ID:
6891
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat spleen, using TAP2 Rabbit pAb (CAB1610) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
