The TAP1 Polyclonal Antibody (CAB6213) is an essential tool for researchers studying the tapasin protein, a critical component of the major histocompatibility complex (MHC) class I antigen processing pathway. This antibody, produced in rabbits, exhibits high specificity and reactivity towards human samples, making it a reliable choice for Western blot applications.Tapasin is involved in the assembly and stabilization of MHC class I molecules, facilitating antigen presentation to cytotoxic T cells. Dysregulation of tapasin expression or function can have significant implications for immune surveillance and immune responses against pathogens or tumor cells. The TAP1 Polyclonal Antibody enables precise detection and analysis of tapasin levels, allowing researchers to investigate its role in various biological processes, including antigen presentation, immune response regulation, and viral evasion mechanisms.
Furthermore, understanding the molecular mechanisms underlying tapasin function is crucial for developing novel immunotherapies and vaccine strategies targeting infectious diseases, cancer, and autoimmune disorders. By utilizing the TAP1 Polyclonal Antibody in their research, scientists can gain valuable insights into the complex interplay between tapasin, MHC class I molecules, and immune surveillance mechanisms, ultimately advancing our knowledge of immune system function and disease pathogenesis.
Product Name:
TAP1 Rabbit Polyclonal Antibody
SKU:
CAB6213
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 524-808 of human TAP1 (NP_000584.3).
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6890
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using TAP1 Rabbit pAb (CAB6213) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
