The TAP1 Monoclonal Antibody is a vital tool for researchers studying the immune system and antigen processing. This antibody, produced using hybridoma technology, specifically targets the TAP1 protein, which plays a key role in the transport of peptides for antigen presentation. With high specificity and sensitivity in detecting TAP1 in human samples, this antibody is ideal for use in techniques such as Western blotting and immunohistochemistry. By binding to TAP1, researchers can analyze the expression and function of this protein in various cell types and tissues, elucidating its role in immune responses and potential implications in diseases such as cancer and autoimmune disorders.
By utilizing the TAP1 Monoclonal Antibody in their experiments, researchers can gain valuable insights into the complex mechanisms of antigen presentation and immune surveillance. This antibody is a valuable tool for advancing our understanding of the immune system and developing new therapeutic strategies for a range of immune-related diseases.
Product Name:
TAP1 Monoclonal Antibody
SKU:
CAB22769
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant funsion protein containing a sequence corresponding to amino acids 449-748 of human TAP1 (NP_000584.2).
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6890
Clone Number:
ARC59005
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using TAP1 Rabbit mAb (CAB22769) at 1:10000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
