Tamm Horsfall Glycoprotein Polyclonal Antibody (CAB22544)
The Tamm-Horsfall Glycoprotein Polyclonal Antibody is a specialized research tool designed for studying the Tamm-Horsfall glycoprotein (THP), a protein found in the urine that plays a key role in kidney function and urinary tract health. This antibody, generated in rabbits, exhibits high sensitivity and specificity when detecting THP in human samples, making it an essential tool for researchers investigating kidney diseases, urinary tract infections, and related conditions.The Tamm-Horsfall Glycoprotein Polyclonal Antibody is validated for use in Western blot applications, enabling researchers to accurately detect and quantify THP levels in various biological samples. By targeting the THP protein, this antibody allows for detailed analysis of its expression, localization, and function in different cell types and tissues, providing valuable insights into the mechanisms underlying kidney function and urinary tract physiology.
Given the critical role of Tamm-Horsfall glycoprotein in maintaining kidney health and urinary tract integrity, this polyclonal antibody is invaluable for studies exploring the pathophysiology of renal disorders, nephrotoxicity, and urinary tract infections. Its ability to specifically recognize and bind to THP makes it a valuable asset for researchers seeking to unravel the complexities of kidney disease and develop targeted therapeutic strategies to improve patient outcomes.
Product Name:
Tamm Horsfall Glycoprotein Polyclonal Antibody
SKU:
CAB22544
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 175-324 of human Tamm Horsfall Glycoprotein. (NP_003352.2).
The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
7369
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of Mouse kidney, using Tamm Horsfall Glycoprotein antibody (CAB22544) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
