The TAL1 Polyclonal Antibody (CAB12927) is a valuable tool for researchers studying TAL1, a transcription factor essential for hematopoietic development. This antibody, raised in rabbits, is highly specific to human TAL1 and has been validated for use in Western blot applications. By binding to the TAL1 protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for research in hematology and oncology.TAL1 is a key regulator of hematopoietic stem cell differentiation, playing a crucial role in blood cell formation and function. Dysregulation of TAL1 expression has been linked to hematologic malignancies such as T-cell acute lymphoblastic leukemia, making it a target of interest for cancer researchers.
Understanding the role of TAL1 in normal and diseased hematopoiesis is essential for the development of targeted therapies and treatment strategies for blood disorders.Overall, the TAL1 Polyclonal Antibody (CAB12927) provides researchers with a reliable tool to study the functions and mechanisms of TAL1 in both normal and pathological hematopoiesis, offering insights into potential therapeutic interventions for hematologic malignancies and other blood-related disorders.
Product Name:
TAL1 Rabbit Polyclonal Antibody
SKU:
CAB12927
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 242-331 of human TAL1 (NP_003180.1).
Enables several functions, including DNA-binding transcription factor activity; E-box binding activity; and histone deacetylase binding activity. Involved in several processes, including myeloid cell differentiation; positive regulation of cellular component organization; and positive regulation of erythrocyte differentiation. Located in chromatin and nucleoplasm. Part of transcription regulator complex. Implicated in acute lymphoblastic leukemia.
Purification Method:
Affinity purification
Gene ID:
6886
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TAL1 Rabbit pAb (CAB12927) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
