The TAL1 Antibody (PAC053778) is a polyclonal antibody specifically designed for research involving TAL1, a transcription factor critical for hematopoiesis and implicated in various hematologic malignancies. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in applications such as Western blotting and immunohistochemistry.TAL1 plays a pivotal role in the regulation of hematopoietic differentiation and has been linked to leukemia and lymphoma development when dysregulated. By targeting the TAL1 protein, this antibody facilitates the detection and analysis of TAL1 expression in different cell types, making it an essential tool for studies in oncology and hematology.
Understanding the mechanisms of TAL1 and its involvement in hematologic disorders is crucial for advancing research and developing novel therapies for patients with these conditions. By utilizing the TAL1 Antibody, researchers can further investigate the roles and functions of TAL1, ultimately contributing to the development of targeted treatments and interventions in the field of hematology.
Antibody Name:
tal1 Antibody (PACO53778)
Antibody SKU:
PACO53778
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Zebrafish
Immunogen:
Recombinant Zebrafish T-cell acute lymphocytic leukemia protein 1 homolog protein (1-324AA)
Western Blot. Positive WB detected in: Zebrafish tissue 20μg, 10μg. All lanes: tal1 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 36, 23 kDa. Observed band size: 36 kDa.
Background:
Transcription factor that plays a pivotal role in hemopoietic and endothelial development, acting synergistically with lmo2 and downstream of clo. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hemopoietic induction cues such as gata1, tal1/scl-lmo2-induced hemangioblasts differentiate into endothelial cells. Isoform α and isoform β are redundant for the initiation of primitive hemopoiesis but have distinct roles in the regulation of primitive erythroid differentiation and definitive hemopoietic stem cell specification, most likely due to differences in expression levels. Specification of definitive hemopoietic stem cells requires isoform beta. DNA binding is required for erythroid maturation, but not for its other hemopoietic functions. Endothelial roles include development of the dorsal aorta, the site of definitive hemopoiesis in the embryo. Required for angiogenesis but not angioblast specification. Has an additional role in endocardium formation during heart development. May play a role in central nervous system development.
Transcription factor that plays a pivotal role in hemopoietic and endothelial development, acting synergistically with lmo2 and downstream of clo. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hemopoietic induction cues such as gata1, tal1/scl-lmo2-induced hemangioblasts differentiate into endothelial cells. Isoform alpha and isoform beta are redundant for the initiation of primitive hemopoiesis but have distinct roles in the regulation of primitive erythroid differentiation and definitive hemopoietic stem cell specification, most likely due to differences in expression levels. Specification of definitive hemopoietic stem cells requires isoform beta. DNA binding is required for erythroid maturation, but not for its other hemopoietic functions. Endothelial roles include development of the dorsal aorta, the site of definitive hemopoiesis in the embryo. Required for angiogenesis but not angioblast specification. Has an additional role in endocardium formation during heart development. May play a role in central nervous system development.
