The TAGAP Polyclonal Antibody (PACO3408) is a valuable tool for researchers studying TAGAP, a protein associated with immune regulation and inflammatory responses. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for Western blot applications. By binding to the TAGAP protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in immunology and cancer research.
TAGAP, also known as T-cell activation RhoGTPase activating protein, plays a crucial role in modulating immune responses and inflammatory pathways. Its involvement in immune system regulation makes it a key target for studying diseases such as cancer, autoimmune disorders, and chronic inflammation. Understanding the function of TAGAP is essential for the development of potential therapies that target or modulate immune responses in these disease contexts.
Antibody Name:
TAGAP Antibody
Antibody SKU:
PACO03408
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human TAGAP.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
TAGAP: an apparent GTPase-activating protein (GAP) for Rho monomeric G proteins. May play important roles during T-cell activation. Mutations have been associated with various autoimmune conditions including rheumatoid arthritis, Crohn¿s disease, and celiac disease. Four isoforms of the human protein are produced by alternative splicing.Protein type: GAPs, Rac/Rho; GAPsChromosomal Location of Human Ortholog: 6q25.3Cellular Component: cytosolMolecular Function: GTPase activator activityBiological Process: regulation of small GTPase mediated signal transduction
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
